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Can I read Adult Depression-like Behavior, Amygdala and Olfactory Cortex Functions Are Restored by Odor Previously Paired with Shock During Infant's Sensitive Period Attachment Learning on EtoBox?
Adult Depression-like Behavior, Amygdala and Olfactory Cortex Functions Are Restored by Odor Previously Paired with Shock During Infant's Sensitive Period Attachment Learning by Yannick Sevelinges; Anne-Marie Mouly; Charlis Raineki; Stéphanie Moriceau; Christina Forest; Regina M. Sullivan is a Neuroscience article available to read on EtoBox.
What is Adult Depression-like Behavior, Amygdala and Olfactory Cortex Functions Are Restored by Odor Previously Paired with Shock During Infant's Sensitive Period Attachment Learning about?
Maltreatment from the caregiver induces vulnerability to later life psychopathologies, yet attraction and comfort is sometimes provided by cues associated with early life maltreatment. We used a rat model of early life maltreatment with odor-0.5 mA shock conditioning to produce depressive-like behaviors and questioned whether stimuli associated with maltreatment would restore emotional neurobehavioral function to control levels. Pups received daily novel odor-0.5 mA shock conditioning from postnatal day 8 to 12. This procedure produces a new maternal odor that controls pups' attachment behaviors. In adulthood, either with or without the infant odor, animals received a Forced Swim Test, Sucrose Preference Test or assessment of amygdala and olfactory system functioning using field potential signal evoked by olfactory bulb paired-pulse electrical stimulation. Following neonatal odor-shock pairings, but not unpaired controls, adults without the odor present showed increased depression-like behavior in the Forced Swim Test and Sucrose Preference Test and a deficit in paired-pulse inhibition in amygdala and piriform (olfactory) cortex. All effects were brought to control levels when the
Who reads Adult Depression-like Behavior, Amygdala and Olfactory Cortex Functions Are Restored by Odor Previously Paired with Shock During Infant's Sensitive Period Attachment Learning?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Yannick Sevelinges; Anne-Marie Mouly; Charlis Raineki; Stéphanie Moriceau; Christina Forest; Regina M. Sullivan
- Publisher
- Elsevier ; Elsevier BV (ISSN 1878-9293)
- Published
- 2011
- Language
- EN
- Field
- Neuroscience (Life Sciences)