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Mapping of C-fos Gene Expression in the Brain During Morphine Dependence and Precipitated Withdrawal, and Phenotypic Identification of the Striatal Neurons Involved by François Georges; Luis Stinus; Catherine Le Moine is a Neuroscience article available to read on EtoBox.

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## Abstract The __c‐fos__ gene is expressed in the central nervous system in response to various neuronal stimuli. Using __in situ__ hybridization, we examined the effects of chronic morphine treatment and withdrawal on __c‐fos__ mRNA in the rat brain, and particularly within identified striatal neurons. Morphine dependence was induced by subcutaneous implantation of two pellets of morphine for 6 days and withdrawal was precipitated by administration of naltrexone. Placebo animals and morphine‐dependent rats showed a very weak __c‐fos__ mRNA expression in all the structures studied. Our study emphasized the spatial variations in __c‐fos__ mRNA expression, and also revealed a peak expression of __c‐fos__ mRNA at 1 h after naltrexone‐precipitated withdrawal in the projection areas of dopaminergic neurons, noradrenergic neurons and in several regions expressing opiate receptors. Interestingly, morphine withdrawal induces __c‐fos__ mRNA expression in the two efferent populations of the striatum (i.e. striatonigral and striatopallidal neurons) both in the caudate putamen and nucleus accumbens. Moreover, the proportions of activated neurons during morphine withdrawal are different in the

Who reads Mapping of C-fos Gene Expression in the Brain During Morphine Dependence and Precipitated Withdrawal, and Phenotypic Identification of the Striatal Neurons Involved?

Author

François Georges; Luis Stinus; Catherine Le Moine

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)

Published

2000

Language

EN

Field

Neuroscience (Life Sciences)