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Multifunctional System Polyaniline-Decorated ZIF-8 Nanoparticles as a New Chemo-Photothermal Platform for Cancer Therapy by Janine S. F. Silva; José Y. R. Silva; Gilberto F. de Sá; Silvany S. Araújo; Manoel A. Gomes Filho; Célia M. Ronconi; Thiago C. Santos; Severino A. Júnior is a Engineering article available to read on EtoBox.

What is Multifunctional System Polyaniline-Decorated ZIF-8 Nanoparticles as a New Chemo-Photothermal Platform for Cancer Therapy about?

Polyaniline-decorated ZIF-8 nanoparticles (nPANI@nZIF-8) were easily synthesized and employed as a multifunctional system for the delivery of the antitumor drug 5-fluorouracil (5-FU). Because of the storage ability of the network ZIF-8, 68% of the total amount of the 5-FU drug was released at pH 5.2. The system exhibits absorption in the near-infrared (NIR) region and can be used in the photothermal therapy owing to the presence of nPANI, which has a strong NIR uptake. This absorption causes local hyperthermia by aiding in the diffusion of the drug molecules contained by the polymer into nPANI@nZIF-8/5-FU achieving a greater release of the 5-FU drug, about 80% activated by an NIR laser (λ = 980 nm). This hyperthermia reached about 70 °C (200 μL, 1 mg mL -1 nPANI@ nZIF-8), which was directly proportional to the concentration of the material. Therefore, our work can aid in the construction of new chemophotothermal platforms that may be employed in cancer therapy.

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Author

Janine S. F. Silva; José Y. R. Silva; Gilberto F. de Sá; Silvany S. Araújo; Manoel A. Gomes Filho; Célia M. Ronconi; Thiago C. Santos; Severino A. Júnior

Published

2018

Language

EN

Field

Engineering (Physical Sciences)