Can I read Improvement in Cardiovascular Autonomic Neuropathy After High-Dose Vitamin D Supplementation in Patients With Type 1 Diabetes on EtoBox?

Improvement in Cardiovascular Autonomic Neuropathy After High-Dose Vitamin D Supplementation in Patients With Type 1 Diabetes by Silva, Lilian de Souza DâAlbuquerque; de Queiroz, Natércia Neves Marques; de Melo, Franciane Trindade Cunha; Abrahão Neto, João Felício; JanaÃo, Luísa CorrÃaa; de Souza Neto, Norberto Jorge Kzan; de Lemos, Manuela Nascimento; de Oliveira, Maria Clara Neres Iunes; de Alcântara, Angélica Leite; de Moraes, Lorena Vilhena; da Silva, Wanderson Maia; de Souza, Ãcaro José AraÃojo; Said, Nivin Mazen; de Lemos, Gabriela Nascimento; Felício, Karem Miléo; Santos, Márcia Costa dos; Motta, Ana Regina Bastos; dos Reis, Melissa de Sá Oliveira; Lobato, Isabel Jane Campos; de Figueiredo, Priscila Boaventura Barbosa; de Souza, Ana Carolina Contente Braga; Piani, Pedro Paulo Freire; Felício, João Soares is a Medicine article available to read on EtoBox.

What is Improvement in Cardiovascular Autonomic Neuropathy After High-Dose Vitamin D Supplementation in Patients With Type 1 Diabetes about?

## Background Cardiovascular autonomic neuropathy (CAN) is associated with diabetes mellitus, increasing morbidity and mortality. Some cross-sectional studies associated CAN with low 25-hydroxyvitamin D levels. The aim of our study was to evaluate the effect of high-dose vitamin D (VD) supplementation on CAN in Type 1 Diabetes Mellitus (T1DM) patients. ## Methods We performed a prospective study with 23 patients diagnosed with T1DM and CAN. Subjects with VD levels <30 ng/ml received 10,000 IU/day; the ones with VD levels between 30–60 ng/ml were given 4,000 IU/day for 12 weeks. ## Results There was an improvement in CAN parameters related to resting heart rate variability, such as time domain parameters [Maximum RR interval (0.77 ± 0.11 vs 0.94 ± 0.51 s, p <0.05), Mean length of regular RR intervals (0.71 ± 0.10 vs 0.76 ± 0.09 s, p <0.05) and Standard deviation of all NN intervals (0.02 ± 0.01 vs 0.03 ± 0.02 s; p <0.01)] and frequency domain parameters [Low Frequency (1.9 ± 0.5 vs 2.5 ± 0.9 s, p < 0.001), Total Power (2.5 ± 0.4 vs 2.8 ± 0.6 s, p <0.05)]. In addition, there was a correlation between absolute VD level variation and posttreatment High Frequency (%), as well as among p

Who reads Improvement in Cardiovascular Autonomic Neuropathy After High-Dose Vitamin D Supplementation in Patients With Type 1 Diabetes?

Author

Silva, Lilian de Souza DâAlbuquerque; de Queiroz, Natércia Neves Marques; de Melo, Franciane Trindade Cunha; Abrahão Neto, João Felício; JanaÃo, Luísa CorrÃaa; de Souza Neto, Norberto Jorge Kzan; de Lemos, Manuela Nascimento; de Oliveira, Maria Clara Neres Iunes; de Alcântara, Angélica Leite; de Moraes, Lorena Vilhena; da Silva, Wanderson Maia; de Souza, Ãcaro José AraÃojo; Said, Nivin Mazen; de Lemos, Gabriela Nascimento; Felício, Karem Miléo; Santos, Márcia Costa dos; Motta, Ana Regina Bastos; dos Reis, Melissa de Sá Oliveira; Lobato, Isabel Jane Campos; de Figueiredo, Priscila Boaventura Barbosa; de Souza, Ana Carolina Contente Braga; Piani, Pedro Paulo Freire; Felício, João Soares

Publisher

Frontiers; Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2010- (ISSN 1664-2392)

Published

2020

Language

EN

Field

Medicine (Health Sciences)