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Exogenous NO Therapy for the Treatment and Prevention of Atherosclerosis by Tommaso Gori is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Exogenous NO Therapy for the Treatment and Prevention of Atherosclerosis about?

Amyl nitrite was introduced in 1867 as the first molecule of a new class of agents for the treatment of angina pectoris. In the following 150 years, the nitric oxide pathway has been the subject of a number of pharmacological approaches, particularly since when this elusive mediator was identified as one of the most important modulators of vascular homeostasis beyond vasomotion, including platelet function, inflammation, and atherogenesis. While having potent antianginal and antiischemic properties, however, nitric oxide donors are also not devoid of side effects, including the induction of tolerance, and, as shown in the last decade, of oxidative stress and endothelial dysfunction. In turn, endothelial dysfunction is itself felt to be involved in all stages of atherogenesis, from the development of fatty streaks to plaque rupture and thrombosis. In the present review, we summarize the agents that act on the nitric oxide pathway, with a particular focus on their potentially beneficial antiatherosclerotic and unwanted pro-atherosclerotic effects.

Who reads Exogenous NO Therapy for the Treatment and Prevention of Atherosclerosis?

Author

Tommaso Gori

Publisher

Molecular Diversity Preservation International; MDPI AG; Multidisciplinary Digital Publishing Institute (MDPI); Basel: MDPI Center, 2000- (ISSN 1422-0067)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)