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Can I read Revisiting Promyelocytic Leukemia Protein Targeting by Human Cytomegalovirus Immediate-early Protein 1 on EtoBox?

Revisiting Promyelocytic Leukemia Protein Targeting by Human Cytomegalovirus Immediate-early Protein 1 by Paulus, Christina; Harwardt, Thomas; Walter, Bernadette; Marxreiter, Andrea; Zenger, Marion; Reuschel, Edith; Nevels, Michael M.; Murphy, Eain A. is a Medicine article available to read on EtoBox.

What is Revisiting Promyelocytic Leukemia Protein Targeting by Human Cytomegalovirus Immediate-early Protein 1 about?

Promyelocytic leukemia (PML) bodies are nuclear organelles implicated in intrinsic and innate antiviral defense. The eponymous PML proteins, central to the self-organization of PML bodies, and other restriction factors found in these organelles are common targets of viral antagonism. The 72-kDa immediate-early protein 1 (IE1) is the principal antagonist of PML bodies encoded by the human cytomegalovirus (hCMV). IE1 is believed to disrupt PML bodies by inhibiting PML SUMOylation, while PML was proposed to act as an E3 ligase for IE1 SUMOylation. PML targeting by IE1 is considered to be crucial for hCMV replication at low multiplicities of infection, in part via counteracting antiviral gene induction linked to the cellular interferon (IFN) response. However, current concepts of IE1-PML interaction are largely derived from mutant IE1 proteins known or predicted to be metabolically unstable and globally misfolded. We performed systematic clustered charge-to-alanine scanning mutagenesis and identified a stable IE1 mutant protein (IE1cc172-176) with wild-type characteristics except for neither interacting with PML proteins nor inhibiting PML SUMOylation. Consequently, IE1cc172-176 does n

Who reads Revisiting Promyelocytic Leukemia Protein Targeting by Human Cytomegalovirus Immediate-early Protein 1?

It is typically read by researchers, students, and practitioners in Medicine.

Author
Paulus, Christina; Harwardt, Thomas; Walter, Bernadette; Marxreiter, Andrea; Zenger, Marion; Reuschel, Edith; Nevels, Michael M.; Murphy, Eain A.
Publisher
Public Library of Science; San Francisco CA: Public Library of Science, [2005]-; Public Library of Science (PLoS) (ISSN 1553-7366)
Published
2020
Language
EN
Field
Medicine (Health Sciences)

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