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This article discusses the design, synthesis, and biological evaluation of novel N-hydroxybenzamides and N-hydroxypropenamides as HDAC inhibitors, highlighting their anticancer properties. The study found that certain derivatives exhibited strong HDAC inhibition and cytotoxicity against cancer cells, with specific structural modifications enhancing their effectiveness. Molecular docking studies provided insights into the structural features critical for the activity of these compounds.

Author

Mayuri Sharma

Language

EN