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Ex vivo lung cancer spheroids resemble treatment response of a patient with NSCLC to chemotherapy and immunotherapy: case report and translational study by Di Liello, Raimondo (author);Ciaramella, Vincenza (author);Barra, Giusi (author);Venditti, Massimo (author);Della Corte, Carminia Maria (author);Papaccio, Federica (author);Sparano, Francesca (author);Viscardi, Giuseppe (author);Iacovino, Maria Lucia (author);Minucci, Sergio (author);Fasano, Morena (author);Ciardiello, Fortunato (author);Morgillo, Floriana (author) is a Medicine article available to read on EtoBox.

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## Introduction In the era of precision medicine, research studies are aiming to design patient-tailored treatment strategies. In this work, we present a clinical case of a patient with non-small cell lung cancer (NSCLC) accompanied by a translational study with the intent to assess the correspondence of drug sensitivity in ex vivo spheroidal tumour cultures and peripheral blood biomarkers with clinical outcome. ## Methods Primary tumour tissue, patient-derived tumour spheroids, peripheral blood mononuclear cells and circulating DNA were analysed to assess drug sensitivity and immunological profiling, and all these data were correlated with clinical and radiological evaluations. ## Results Immunohistochemistry, immunofluorescence, next generation sequencing analysis and T-lymphocyte receptor repertoire assay results showed elevated concordance among primary tumour tissue, ex vivo three-dimensional tumour spheroid specimen and circulating DNA. Cisplatin-based chemotherapy and anti-programmed death 1 drug sensitivity assessed in spheroidal cultures were strictly consistent with patient clinical response to adjuvant chemotherapy and first-line immune therapy. ## Conclusion These resul

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Author

Di Liello, Raimondo (author);Ciaramella, Vincenza (author);Barra, Giusi (author);Venditti, Massimo (author);Della Corte, Carminia Maria (author);Papaccio, Federica (author);Sparano, Francesca (author);Viscardi, Giuseppe (author);Iacovino, Maria Lucia (author);Minucci, Sergio (author);Fasano, Morena (author);Ciardiello, Fortunato (author);Morgillo, Floriana (author)

Publisher

BMJ Publishing Group

Published

2019

Language

EN

Field

Medicine (Health Sciences)