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Models of communication for polygenic scores and associated psychosocial and behavioral effects on recipients: A systematic review by Courtney K. Wallingford; Hannah Kovilpillai; Chris Jacobs; Erin Turbitt; Clare A. Primiero; Mary-Anne Young; Deanna G. Brockman; H. Peter Soyer; Aideen M. McInerney-Leo; Tatiane Yanes is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Models of communication for polygenic scores and associated psychosocial and behavioral effects on recipients: A systematic review about?
Purpose This study aimed to systematically review current models for communicating polygenic scores (PGS) and psycho-behavioral outcomes of receiving PGSs. Methods Original research on communicating PGSs and reporting on psycho-behavioral outcomes was included. Search terms were applied to 5 databases and were limited by date (2009-2021). Results In total, 28 articles, representing 17 studies in several disease settings were identified. There was limited consistency in PGS communication and evaluation/reporting of outcomes. Most studies (n = 14) presented risk in multiple ways (ie, numerically, verbally, and/or visually). Three studies provided personalized lifestyle advice and additional resources. Only 1 of 17 studies reported using behavior change theory to inform their PGS intervention. A total of 8 studies found no evidence of long-term negative psychosocial effects up to 12 months post result. Of 14 studies reporting on behavior, 9 found at least 1 favorable change after PGS receipt. When stratified by risk, 7 out of 9 studies found high PGS was associated with favorable changes including lifestyle, medication, and screening. Low-risk PGS was not associated with maladaptive b
Who reads Models of communication for polygenic scores and associated psychosocial and behavioral effects on recipients: A systematic review?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Courtney K. Wallingford; Hannah Kovilpillai; Chris Jacobs; Erin Turbitt; Clare A. Primiero; Mary-Anne Young; Deanna G. Brockman; H. Peter Soyer; Aideen M. McInerney-Leo; Tatiane Yanes
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)