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Can I read Qualitative Drug Analysis of Hair Extracts by Comprehensive Two-dimensional Gas Chromatography/time-of-flight Mass Spectrometry on EtoBox?
Qualitative Drug Analysis of Hair Extracts by Comprehensive Two-dimensional Gas Chromatography/time-of-flight Mass Spectrometry by Bill Guthery; Tom Bassindale; Alan Bassindale; Colin T. Pillinger; Geraint H. Morgan is a Chemistry article available to read on EtoBox.
What is Qualitative Drug Analysis of Hair Extracts by Comprehensive Two-dimensional Gas Chromatography/time-of-flight Mass Spectrometry about?
A technique using comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry (GC × GC/TOFMS) is applied to a qualitative analysis of three sample extracts from hair suspected of containing various drug compounds. The samples were also subjected to a quantitative target analysis for codeine, morphine, 6-monoacetylmorphine (6-MAM), amphetamine, methamphetamine, methylenedioxyamphetamine (MDA), methylenedioxymethylamphetamine (MDMA), methadone, and benzylpiperazine (BZP) by liquid chromatography-tandem mass spectrometry (LC-MS/MS). GC × GC/TOFMS provided a non-specific procedure that identified various drugs, metabolites, and impurities not included in the target analysis. They included cocaine, diazepam, and methaqualone (quaalude). Comprehensive GC × GC separation was achieved using twin-stage cryo-modulation to focus eluant from a DB-5ms (5% phenyl) to a BPX50 (50% phenyl) GC column. The TOF mass spectrometer provided unit mass resolution in the mass range m/z 5-1000 and rapid spectral acquisition (≤500 spectra/s). Clean mass spectra of the individual components were obtained using mass spectral deconvolution software. The 'unknown' components were identified
Who reads Qualitative Drug Analysis of Hair Extracts by Comprehensive Two-dimensional Gas Chromatography/time-of-flight Mass Spectrometry?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Bill Guthery; Tom Bassindale; Alan Bassindale; Colin T. Pillinger; Geraint H. Morgan
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-3778)
- Published
- 2010
- Language
- EN
- Field
- Chemistry (Physical Sciences)