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Can I read The Active Fraction of Polyrhachis vicina Roger (AFPR) activates ERK to cause necroptosis in colorectal cancer on EtoBox?
The Active Fraction of Polyrhachis vicina Roger (AFPR) activates ERK to cause necroptosis in colorectal cancer by Dong-mei Li; Fu-cui Zhu; Jie Wei; Jia-xiu Xie; Jun-hui He; Dong-mei Wei; Yi Li; Ke-dao Lai; Li-min Liu; Qi-biao Su; Gui-ning Wei; Bin Wang; Yan-cheng Liu is a Agricultural and Biological Sciences article available to read on EtoBox.
What is The Active Fraction of Polyrhachis vicina Roger (AFPR) activates ERK to cause necroptosis in colorectal cancer about?
Ethnopharmacological relevance Polyrhachis vicina Roger (P. vicina), a traditional Chinese medicinal animal, has been used to treat rheumatoid arthritis, hepatitis, cancer, and other conditions. Due to its anti-inflammatory properties, our previous pharmacological investigations have demonstrated that it is effective against cancer, depression, and hyperuricemia. Nevertheless, the key active components and targets of P. vicina in cancers are still unexplored. Aim of the study The study aimed to evaluate the pharmacological treatment mechanism of the active fraction of P. vicina (AFPR) in treating colorectal cancer (CRC) and to further reveal its active ingredients and key targets. Methods To examine the inhibitory impact of AFPR on CRC growth, tumorigenesis assays, cck-8 assays, colony formation assays, and MMP detection were utilized. The primary components of AFPR were identified by GC-MS analysis. The network pharmacology, molecular docking, qRT-PCR, western blotting, CCK-8 assays, colony formation assay, Hoechst staining, Annexin V-FITC/PI double staining, and MMP detection were performed to pick out the active ingredients and potential key targets of AFPR. The function of Elai
Who reads The Active Fraction of Polyrhachis vicina Roger (AFPR) activates ERK to cause necroptosis in colorectal cancer?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Dong-mei Li; Fu-cui Zhu; Jie Wei; Jia-xiu Xie; Jun-hui He; Dong-mei Wei; Yi Li; Ke-dao Lai; Li-min Liu; Qi-biao Su; Gui-ning Wei; Bin Wang; Yan-cheng Liu
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)