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Runx1/AML1 in leukemia: disrupted association with diverse protein partners by Chava Perry; Amiram Eldor; Hermona Soreq is a Medicine article available to read on EtoBox.

What is Runx1/AML1 in leukemia: disrupted association with diverse protein partners about?

Runx1/AML1, a chromosome 21q22 hematopoietic regulator, is frequently translocated in leukemia. Its protein product, a relatively weak transcriptional activator, becomes an effective transcriptional enhancer or repressor, when co-operating with transcriptional co-activators or co-repressors. Runx1/AML1 association with its partners is disrupted in leukemia. For example, Runx1/AML1 mutations and translocations (e.g. t(8;21), t(12;21) and t(3;21)) impair binding of Runx1/AML1-CBFb complexes to Runt motifs in myelopoietically active promoters, preventing normal hematopoiesis. However, Runx1/AML1-associated translocations are not leukemogenic in animal models, suggesting the involvement of yet unidentified regulatory proteins. New candidates are cholinesterases, inhibition of which increases leukemic risk in a manner potentially associated with Runx1/AML1.

Who reads Runx1/AML1 in leukemia: disrupted association with diverse protein partners?

Author

Chava Perry; Amiram Eldor; Hermona Soreq

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0145-2126)

Published

2002

Language

EN

Field

Medicine (Health Sciences)