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What is Shear-Mediated ALK5 Expression Regulates Endothelial Activation about?

This study investigates the role of the TGF-b receptor ALK5 in endothelial activation under shear stress conditions, particularly in the context of calcific aortic valve disease (CAVD). It was found that low magnitude multidirectional flow (LMMF) downregulates ALK5 expression, increases SMAD2 phosphorylation, and enhances monocyte adhesion and transendothelial transport, suggesting ALK5

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729648zx

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