Opening book details…
Can I read (353) Pre-Transplant Sensitization is Associated with Lower Levels of Immunomodulatory Metabolite Concentrations after Heart Transplantation on EtoBox?
(353) Pre-Transplant Sensitization is Associated with Lower Levels of Immunomodulatory Metabolite Concentrations after Heart Transplantation by J. Han; M. Dela Cruz; H. Lin; E. Adler; M. Khalid; J. Cantoral; A. Moran; A. Sundararajan; A. Sidebottom; M. Alegre; E. Pamer; A. Nguyen is a Medicine article available to read on EtoBox.
What is (353) Pre-Transplant Sensitization is Associated with Lower Levels of Immunomodulatory Metabolite Concentrations after Heart Transplantation about?
Purpose Certain gut microbiome derived metabolites have been shown to have a protective immunomodulatory role in transplantation. We sought to investigate whether sensitization in patients undergoing heart transplantation (HT) is associated with gut metabolite concentrations. Methods This is a single-center prospective study of all HTs performed from July 2020 to May 2022. Stool samples were collected within two weeks peri-transplant. Shotgun metagenomics was used to analyze microbiome compositions and mass spectrometry was used to analyze gut microbiome metabolites. Sensitization was defined as calculated panel reactive antibodies class I or II >10% or class I+II >10%. Gut microbiome composition, diversity, and metabolites were compared between sensitized and non-sensitized (NS) groups. Results There were 19 (27.1%) sensitized and 51 (72.9%) NS recipients. A total of 18 (25.7%) patients were multi-organ recipients (heart-kidney or heart-liver). Sensitized patients were more likely to be female (53% vs. 20%, p=0.007) with otherwise similar baseline characteristics and six month mortality. There was no difference in α-diversity between the two groups. On compositional analysis, ther
Who reads (353) Pre-Transplant Sensitization is Associated with Lower Levels of Immunomodulatory Metabolite Concentrations after Heart Transplantation?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- J. Han; M. Dela Cruz; H. Lin; E. Adler; M. Khalid; J. Cantoral; A. Moran; A. Sundararajan; A. Sidebottom; M. Alegre; E. Pamer; A. Nguyen
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)