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Serotonergic Signaling Plays a Deeply Conserved Role in Improving Oocyte Quality by Erin Z. Aprison; Svetlana Dzitoyeva; Ilya Ruvinsky is a scholarly article available to read on EtoBox.

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Abstract Declining germline quality is a major cause of reproductive senescence. Potential remedies could be found by studying regulatory pathways that promote germline quality. Several lines of evidence, including aC. elegansmale pheromone ascr#10 that counteracts the effects of germline aging in hermaphrodites, suggest that the nervous system plays an important role in regulating germline quality. Inspired by the fact that serotonin mediates ascr#10 signaling, here we show that serotonin reuptake inhibitors recapitulate the effects of ascr#10 on the germline and promote healthy oocyte aging inC. elegans. Surprisingly, we found that pharmacological increase of serotonin signaling stimulates several developmental processes inD. melanogaster, including improved oocyte quality, although underlying mechanisms appear to be different between worms and flies. Our results reveal a plausibly conserved role for serotonin in maintaining germline quality and identify a class of therapeutic interventions using available compounds that could efficiently forestall reproductive aging.

Author

Erin Z. Aprison; Svetlana Dzitoyeva; Ilya Ruvinsky

Publisher

Cold Spring Harbor Laboratory

Published

2023

Language

EN