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Chromosome-9 Loss Detected by Fluorescencein Situ Hybridization in Bladder Cancer by Guido Sauter; Holger Moch; Peter Carroll; Russel Kerschmann; Michael J. Mihatsch; Frederic M. Waldman is a Medicine article available to read on EtoBox.

What is Chromosome-9 Loss Detected by Fluorescencein Situ Hybridization in Bladder Cancer about?

A loss of chromosome-9 material is one of the most frequent genomic aberrations known in bladder cancer. In order to better understand the role of chromosome-9 losses in bladder cancer, I25 formalin-fixed and 37 unfixed bladder tumors were examined using fluorescence in situ hybridization (FISH). A repetitive probe for a pericentromeric region on 9q I2 (pHUR98) was applied for chromosome-9 copy-number enumeration. Under-representation of chromosome 9 was found in 74 of I62 cases. There was no association between loss of chromosome 9 and increased grade or stage, papillary growth pattern, p53 protein expression, or tumor-cell proliferation (Ki-67). These data show that chromosome-9 loss is an early event in bladdercancer development, occuring independently of p53 alterations. In order to determine the prevalence of large sub-regional chromosome-9 deletions, dual hybridizations with pHUR 98 and cosmid probes for 9q34, 9q22, and 9p21 were performed. Partial deletion was detected in only I of 36 cases for 9q34 and in I of 24 cases for 9 ~2 1 . Surprisingly, amplification of the interferon alpha locus on 9p2 I was seen in I of 24 tumors. The finding of 9p amplification may indicate the

Who reads Chromosome-9 Loss Detected by Fluorescencein Situ Hybridization in Bladder Cancer?

Author

Guido Sauter; Holger Moch; Peter Carroll; Russel Kerschmann; Michael J. Mihatsch; Frederic M. Waldman

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

1995

Language

EN

Field

Medicine (Health Sciences)