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Hydrogen Sulfide Dual-Activated NIR-II Photoacoustic Probes for Accurate Imaging and Efficient Photothermal Therapy of Colon Cancer by Wang, Shulong ;Zhang, Liangliang ;Zhao, Jingjin ;Hou, Li ;Wen, Changchun ;Liang, Hong ;Zhao, Shulin is a scholarly article available to read on EtoBox.

What is Hydrogen Sulfide Dual-Activated NIR-II Photoacoustic Probes for Accurate Imaging and Efficient Photothermal Therapy of Colon Cancer about?

Hydrogen sulfide (H 2 S) content has been shown to be significantly increased in colon cancer tissue; imaging H 2 S in vivo enables the accurate diagnosis of colon cancer disease. Photoacoustic (PA) imaging is a biological imaging mode combining photoexcitation and ultrasonic detection, and high-resolution imaging in deep biological tissues can be achieved using PA probes in the second near-infrared biowindow (NIR-II). Nevertheless, existing materials can only be used as contrast agents to achieve the PA imaging of biomolecules in NIR-II, which still remains a challenge. To this end, water-soluble MoO 3 nanoparticles were prepared, and it was found that PA imaging and photothermal therapy (PTT) of colon cancer tissue can be specifically activated in NIR-II by endogenous H 2 S. Therefore, MoO 3 nanoparticles were used as an NIR-II nanoprobe for PA imaging and PTT of colon cancer tissue. Furthermore, by comparing the efficiency for the PA imaging and PTT of colon cancer in NIR-I and NIR-II, it was proven that in the NIR-II window, the background interference of the PA imaging for biological tissue was low, the photothermal efficiency was high, and the PTT effect was good. This work d

Author

Wang, Shulong ;Zhang, Liangliang ;Zhao, Jingjin ;Hou, Li ;Wen, Changchun ;Liang, Hong ;Zhao, Shulin

Publisher

American Chemical Society (ACS)

Published

2021

Language

EN