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Amines are less acidic than alcohols due to the lower electronegativity of nitrogen compared to oxygen, which affects the release of H⁺ ions. Aromatic primary amines cannot be synthesized via Gabriel phthalimide synthesis because aryl halides do not undergo nucleophilic substitution effectively. Aniline does not participate in Friedel-Crafts reactions due to the donation of its lone pair to Lewis acid catalysts, deactivating the aromatic ring.
- Author
- sriammansteelserode
- Language
- EN