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Association of serum osmolality with all-cause and cardiovascular mortality in US adults: A prospective cohort study by Sibo Wang; Di Zhao; Tongtong Yang; Bo Deng; Jiateng Sun; Lingfeng Gu; Hao Wang; Liansheng Wang is a Medicine article available to read on EtoBox.
What is Association of serum osmolality with all-cause and cardiovascular mortality in US adults: A prospective cohort study about?
Background and aims The association between serum osmolality, an effective indicator of body hydration status, and long-term mortality in the general population remains undetermined. The present study aimed to investigate the association of serum osmolality with long-term all-cause and cardiovascular mortality among adults in the United States. Methods and results This cohort study used data from the National Health and Nutrition Examination Survey (NHANES) 2007–2014. Participants were linked to National Death Index mortality data from the survey date through December 31, 2019. Cox proportional hazards regression model was used to calculate hazard ratios (HRs) and 95% CIs, and restricted cubic spline (RCS) regression was conducted. A total of 18312 US adults were included. During a median follow-up of 8.7 years, 1353 total deaths occurred, including 379 cardiovascular deaths. After multivariable adjustments, compared with the 3rd quartile (Q3) of serum osmolality, participants in the 1st (Q1) and 4th (Q4) quartiles were at a significantly higher risk of all-cause mortality (HR 1.41 [95% CI, 1.14–1.75] and 1.29 [95% CI, 1.04–1.61], respectively). RCS revealed a nonlinear relationshi
Who reads Association of serum osmolality with all-cause and cardiovascular mortality in US adults: A prospective cohort study?
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- Author
- Sibo Wang; Di Zhao; Tongtong Yang; Bo Deng; Jiateng Sun; Lingfeng Gu; Hao Wang; Liansheng Wang
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)