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High incidence of autoantibodies in Taiwanese patients with oral submucous fibrosis by C. P. Chiang; R. P. Hsieh; T. H. H. Chen; Y. F. Chang; B. Y. Liu; J. T. Wang; A. Sun; M. Y. P. Kuo is a scholarly article available to read on EtoBox.

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## Abstract **Background:** Previous study has shown a high incidence of autoantibodies including antinuclear (ANA), antismooth muscle (SMA), antigastric parietal cell (GPCA), antithyroid microsomal (TMA), and antireticulin antibodies in a small group of 26 patients with oral submucous fibrosis (OSF). The reasons why some of the OSF patients have high titers of autoantibodies in serum have not been completely explained and no further study on autoantibodies in OSF patients has been done in a large group of patients. **Methods:** In this study, we determined the serum levels of ANA, SMA, GPCA, and TMA in a large group of 109 male Taiwanese patients with OSF by an indirect immunofluorescence technique (for ANA, SMA, and GPCA), and by a semiquantitative microtiter particle agglutination test (for TMA). The presence of serum autoantibodies in OSF patients was further correlated with patients' oral habits and the severity of OSF measured by maximum mouth opening (MMO) and sites of involvement. **Results:** We found that the frequencies of presence of serum ANA (23.9%), SMA (23.9%), and GPCA (14.7%) in OSF patients were significantly higher than those (9.2, 7.3, and 5.5%, respectively) i

Author

C. P. Chiang; R. P. Hsieh; T. H. H. Chen; Y. F. Chang; B. Y. Liu; J. T. Wang; A. Sun; M. Y. P. Kuo

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0904-2512)

Published

2002

Language

EN