Can I read Comparative Anticholinergic Activity of Oxaprotiline and Amitriptyline on EtoBox?

Comparative Anticholinergic Activity of Oxaprotiline and Amitriptyline by Mark Roffman; Eugene Gould; Samuel Brewer; Helen Lau; Barry Sachais; Dr. Nina Dixon; Linda Kaczmarek; Anne Le Sher is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Comparative Anticholinergic Activity of Oxaprotiline and Amitriptyline about?

As part of a double-blind multicenter trial comparing oxaprotiline with amitriptyline and placebo in 308 outpatients with moderate depression, objective (salivary flow) and subjective (dry mouth, blurred visionlvisual disorder, and constipation) determinants of anticholinergic activity were assessed. Both active treatments, but not placebo, induced approximately a 40% reduction in salivary flow after one week of treatment with 75 mgl day h.s. Whereas amitriptyline caused a further reduction (26%) in salivary flow by the end of the trial (week 5), no such reduction was noted with oxaprotiline. With regards to subjective complaints, more patients experienced dry mouth and blurred vision/visual

Who reads Comparative Anticholinergic Activity of Oxaprotiline and Amitriptyline?

Author

Mark Roffman; Eugene Gould; Samuel Brewer; Helen Lau; Barry Sachais; Dr. Nina Dixon; Linda Kaczmarek; Anne Le Sher

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0272-4391)

Published

1983

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)