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This study reveals that the interaction between SynGAP and PSD-95 in postsynaptic densities leads to phase separation, forming liquid-like droplets that are crucial for synaptic complex formation and plasticity. The multivalent binding of SynGAP to PSD-95 enhances its stability within the postsynaptic density and is linked to activity-dependent modulation. These findings provide insights into the molecular mechanisms underlying synaptic function and the impact of mutations on brain disorders such as autism

Author

sunhuanyu66

Language

EN