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Can I read Nix-mediated Mitophagy Modulates Mitochondrial Damage during Intestinal Inflammation on EtoBox?
Nix-mediated Mitophagy Modulates Mitochondrial Damage during Intestinal Inflammation by Garret Vincent; Elizabeth A. Novak; Vei Shaun Siow; Kellie E. Cunningham; Brian D. Griffith; Thomas E. Comerford; Heather L. Mentrup; Donna B. Stolz; Patricia Loughran; Sarangarajan Ranganathan; Kevin P. Mollen is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Nix-mediated Mitophagy Modulates Mitochondrial Damage during Intestinal Inflammation about?
Mitochondrial stress and dysfunction within the intestinal epithelium are known to contribute to the pathogenesis of inflammatory bowel disease (IBD). However, the importance of mitophagy during intestinal inflammation remains poorly understood. The primary aim of this study was to investigate how the mitophagy protein BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L/NIX) mitigates mitochondrial damage during intestinal inflammation in the hopes that these data will allow us to target mitochondrial health in the intestinal epithelium as an adjunct to immune-based treatment strategies. In the intestinal epithelium of patients with ulcerative colitis, we found that NIX was upregulated and targeted to the mitochondria. We obtained similar findings in wild-type mice undergoing experimental colitis. An increase in NIX expression was found to depend on stabilization of hypoxia-inducible factor-1 alpha (HIF1α), which binds to the promoter region. Using the reactive oxygen species (ROS) scavenger MitoTEMPO, we were able to attenuate disease and inhibit both HIF1α stabilization and subsequent NIX expression, suggesting that mitochondrially derived ROS are crucial to ini
Who reads Nix-mediated Mitophagy Modulates Mitochondrial Damage during Intestinal Inflammation?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Garret Vincent; Elizabeth A. Novak; Vei Shaun Siow; Kellie E. Cunningham; Brian D. Griffith; Thomas E. Comerford; Heather L. Mentrup; Donna B. Stolz; Patricia Loughran; Sarangarajan Ranganathan; Kevin P. Mollen
- Publisher
- Mary Ann Liebert; Mary Ann Liebert Inc.; Mary Ann Liebert Inc (ISSN 1523-0864)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)