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The Sickle Cell Pro-Inflammatory Response to Interval Testing Study (SPRINTS) in children and young adults with sickle cell anemia – Study design and methodological strategies by Liem, R.I.; Baynard, T.; Hsu, L.L.; Garofano, R.; Green, N.S.; Hankins, J.S.; Ness, K.K.; Rodeghier, M.; Radom-Aizik, S. is a Medicine article available to read on EtoBox.
What is The Sickle Cell Pro-Inflammatory Response to Interval Testing Study (SPRINTS) in children and young adults with sickle cell anemia – Study design and methodological strategies about?
The impact of sickle cell anemia (SCA) and its complications on physical functioning and cardiopulmonary/aerobic fitness in affected individuals is significant. Although limited data support the safety of maximal cardiopulmonary exercise testing (CPET) for children and adults with SCA, the safety of submaximal moderate and high intensity, and longer duration, exercise in this population is not clear. The Sickle Cell Pro-Inflammatory Response to Interval Testing Study (SPRINTS) is a multicenter, randomized, prospective trial. SPRINTS leverages unique collaborations between investigators in pediatric hematology and exercise science to evaluate the impact of exercise intensity on the acute phase inflammatory response to exercise and changes in airway dynamics in children and young adults with SCA. Here we describe the study design and methodological strategies employed in SPRINTS, including an exercise challenge that mimics real-life patterns of childhood physical activity, characterized by multiple moderate and high intensity brief bouts of exercise interspersed with rest periods. Primary outcomes comprise pre- and post-exercise biomarkers of inflammation and endothelial dysfunction
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- Author
- Liem, R.I.; Baynard, T.; Hsu, L.L.; Garofano, R.; Green, N.S.; Hankins, J.S.; Ness, K.K.; Rodeghier, M.; Radom-Aizik, S.
- Publisher
- Elsevier ; Elsevier Inc.; [New York]: Elsevier Inc.; Elsevier BV (ISSN 2451-8654)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)