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Postnatal Development of the Collagen Matrix in Rabbit Tibial Plateau Articular Cartilage by JOHN M. CLARK; ANTHONY NORMAN; HUBERT NÖTZLI is a Earth and Planetary Sciences article available to read on EtoBox.

What is Postnatal Development of the Collagen Matrix in Rabbit Tibial Plateau Articular Cartilage about?

Changes in the 3‐dimensional arrangement of the articular cartilage matrix during growth of the rabbit tibial plateau were studied. Knees from newborn, and 1, 2 and 6 wk‐old rabbits were compared with those of adults by light and electron microscopy. The specimens were fixed, embedded en bloc in epoxy resin and sectioned vertically/coronally through the point where the articular cartilage was thickest in the adult medial tibial plateau. At birth, the proximal tibial epiphysis was cartilaginous, but nascent articular cartilage was recognisable as a densely cellular layer covering the tibial condyle. Within 30 μm of the articular surface, the chondrocytes were flattened and collagen fibres ran among these cells in a direction parallel to the surface. Deeper in the articular cartilage, rounded cells were evenly distributed within a random collagen fibril network. At the centre of the plateau, the tangential layer changed little during growth, whereas the subjacent cellular layer grew in thickness and steadily achieved a more vertical character in the organisation of its constituent collagen and cellular elements. At 1 wk, cells were separated into clusters by acellular regions filled

Who reads Postnatal Development of the Collagen Matrix in Rabbit Tibial Plateau Articular Cartilage?

Author

JOHN M. CLARK; ANTHONY NORMAN; HUBERT NÖTZLI

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0021-8782)

Published

1997

Language

EN

Field

Earth and Planetary Sciences (Physical Sciences)