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What is Inhibition of Replication Origins and ATR Synergis about?

This study investigates a novel strategy to enhance ATR inhibitor effectiveness in ovarian cancer by inhibiting replication origin activation, which sensitizes cancer cells to ATR inhibition and increases genomic instability. The combined approach activates the innate immune system via the cGAS-STING pathway, potentially improving immune responses within tumors while sparing normal cells. These findings suggest a promising therapeutic avenue for targeting ovarian cancer with genomic instability and dysregul

Author

amandabertolato

Language

EN