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Can I read A Comparative Evaluation of the Biostability of a Poly (Ether Urethane) in the Intraocular, Intramuscular, and Subcutaneous Environments on EtoBox?
A Comparative Evaluation of the Biostability of a Poly (Ether Urethane) in the Intraocular, Intramuscular, and Subcutaneous Environments by F. Richard Christ; Shelley Y. Buchen; David A. Fencil; Patricia M. Knight; Kerry D. Solomon; David J. Apple is a Medicine article available to read on EtoBox.
What is A Comparative Evaluation of the Biostability of a Poly (Ether Urethane) in the Intraocular, Intramuscular, and Subcutaneous Environments about?
A transparent poly (ether urethane) (PEU) was considered for use as a foldable intraocular lens material. The PEU was found to possess excellent mechanical, optical, and surface characteristics for this application. In uitro hydrolytic and ultraviolet aging studies suggested the PEU to be tolerant to conditions simulating 3-10 years of normal intraocular exposure. Different behavior was obtained, however, from intraocular and subcutaneous implantation of the PEU. After 6 months of intraocular exposure in the feline model, prototype PEU lenses had lost most or all of their optical resolving power. SEM analysis demonstrated scat-tered pitting and cracking on the lens surfaces. Degradation was found to be more extreme after as little as 30 days of subcutaneous exposure in rabbits. Severe pitting over the entire surface of implanted f l a t PEU specimens was observed by SEM. Macroscopic examination showed the samples to be frosty in appearance. It was postulated that the subcutaneous implant environment provides an accelerated in uivo model for materials intended for intraocular use. A minimum acceleration of 6-1OX was estimated on a preliminary basis. The PEU studied here was found to
Who reads A Comparative Evaluation of the Biostability of a Poly (Ether Urethane) in the Intraocular, Intramuscular, and Subcutaneous Environments?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- F. Richard Christ; Shelley Y. Buchen; David A. Fencil; Patricia M. Knight; Kerry D. Solomon; David J. Apple
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Heterocorporation; Wiley (ISSN 0021-9304)
- Published
- 1992
- Language
- EN
- Field
- Medicine (Health Sciences)