About this Medicine article
Dosage Prescribing and Plasma Oxipurinol Levels in Patients Receiving Allopurinol Therapy by G. M. Peterson; R. R. Boyle; H. W. Francis; N. W. J. Oliver; J. Paterson; R. J. von Witt; G. R. Taylor is a Medicine article available to read on EtoBox.
This study examined dosage prescribing patterns and steady-state oxipurinol plasma concentrations in 66 patients receiving chronic allopurinol therapy. Most patients (65%) were taking 300 mg allopurinol daily, although renal impairment was common. Using published guidelines, it was estimated that 35% of patients were receiving excessive dosages of allopurinol. Consequently, the plasma oxipurinol concentrations were often very high (mean (SD) was 156 (109) mumol.l-1). Accumulation of oxipurinol was inversely related to renal function. Plasma concentrations of oxipurinol and urate were not significantly related. However, most patients with oxipurinol concentrations of up to 100 mumol.l-1 had urate concentrations within the normal reference range.
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- Author
- G. M. Peterson; R. R. Boyle; H. W. Francis; N. W. J. Oliver; J. Paterson; R. J. von Witt; G. R. Taylor
- Publisher
- Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0031-6970)
- Published
- 1990
- Language
- EN
- Field
- Medicine (Health Sciences)