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Reduction of Protein Adsorption on Well-characterized Polymer Brush Layers with Varying Chemical Structures by Yuuki Inoue; Kazuhiko Ishihara is a Materials Science article available to read on EtoBox.

What is Reduction of Protein Adsorption on Well-characterized Polymer Brush Layers with Varying Chemical Structures about?

To clarify protein adsorption behavior on polymer brush layers, surface characteristics and protein adsorption repellency on polymer brush layers should be precisely determined. Here, we clearly delineated the chemical structure of the polymer brush layers containing various hydrophilic groups, namely, phosphorylcholine, sulfoxybetaine, carboxybetaine (zwitterionic), and hydroxyl group (nonionic) and examined the effects of the chemical structure on initial protein adsorption behavior. Kinetic analysis performed during surface-initiated atom transfer radical polymerization revealed that graft polymerization proceeded in a living manner. The graft density of each type of polymer chain and its surface coverage were high enough to form dense polymer brush structures. The hydroxyl group-bearing polymer brush structure exhibited the highest graft density. Among the zwitterionic polymer brush structures, the graft density and surface coverage of sulfoxybetaine-and carboxybetaine-bearing polymer chains were higher than those of the phosphorylcholine-bearing polymer chains. The amount of protein relative to 100% serum adsorbed on polymer brush layers was quantified using quartz crystal mic

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Author

Yuuki Inoue; Kazuhiko Ishihara

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0927-7765)

Published

2010

Language

EN

Field

Materials Science (Physical Sciences)