Can I read Thermodynamics of accuracy in kinetic proofreading: Dissipation and efficiency trade-offs on EtoBox?

Thermodynamics of accuracy in kinetic proofreading: Dissipation and efficiency trade-offs by Rao, Riccardo; Peliti, Luca is a scholarly article available to read on EtoBox.

What is Thermodynamics of accuracy in kinetic proofreading: Dissipation and efficiency trade-offs about?

The high accuracy exhibited by biological information transcription processes is due to kinetic proofreading, i.e., by a mechanism which reduces the error rate of the information-handling process by driving it out of equilibrium. We provide a consistent thermodynamic description of enzyme-assisted assembly processes involving competing substrates, in a Master Equation framework. We introduce and evaluate a measure of the efficiency based on rigorous non-equilibrium inequalities. The performance of several proofreading models are thus analyzed and the related time, dissipation and efficiency vs. error trade-offs exhibited for different discrimination regimes. We finally introduce and analyze in the same framework a simple model which takes into account correlations between consecutive enzyme-assisted assembly steps. This work highlights the relevance of the distinction between energetic and kinetic discrimination regimes in enzyme-substrate interactions.

Author

Rao, Riccardo; Peliti, Luca

Published

2015

Language

EN