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Can I read Salvianolic acid B suppresses hepatic stellate cell activation and liver fibrosis by inhibiting the NF-κB signaling pathway via miR-6499-3p/LncRNA-ROR on EtoBox?
Salvianolic acid B suppresses hepatic stellate cell activation and liver fibrosis by inhibiting the NF-κB signaling pathway via miR-6499-3p/LncRNA-ROR by Rong Wang; Shengnan Li; Panpan Chen; Xin Yue; Shaozhan Wang; Yanqiu Gu; Yongfang Yuan is a Medicine article available to read on EtoBox.
What is Salvianolic acid B suppresses hepatic stellate cell activation and liver fibrosis by inhibiting the NF-κB signaling pathway via miR-6499-3p/LncRNA-ROR about?
## Background: Long non-coding rna (lncrnas) have been reported to play an important role in liver fibrosis and are closely associated with hepatic stellate cell (hsc) activation. we previously found that salvianolic acid b (sal b) improves liver fibrosis by regulating the nf-κb signaling pathway. however, whether the lncrna, regulator of reprogramming (lncrna-ror) plays a role in sal b-mediated anti-fibrosis effects via the nf-κb signaling pathway remain unclear. ## Purpose: This study aimed to evaluate the effects of sal b on hsc activation and liver fibrosis and investigate its mechanism from the perspective of lncrna-ror-mediated nf-κb signaling pathways. ## Methods: Lx-2 and t6 cell lines were cultured. animal models of liver fibrosis were established using ccl in male balb/c mice. primary hscs were isolated from mice and cultured. serum biochemical and liver histological analyses were performed to evaluate the effects of sal b on liver fibrosis. the index of hsc activation and the expression of lncrna-ror, micrornas (mirnas), and inflammatory factors were determined by quantitative real-time reverse transcription-polymerase chain reaction (qrt-pcr) or immunofluorescence stain
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- Author
- Rong Wang; Shengnan Li; Panpan Chen; Xin Yue; Shaozhan Wang; Yanqiu Gu; Yongfang Yuan
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Medicine (Life Sciences)