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Intermediate‐term Outcomes of Heart Transplantation for Cardiac Amyloidosis in the Current Era by Gaurang N. Vaidya; Jignesh K. Patel; Michelle Kittleson; David H. Chang; Evan Kransdorf; Dael Geft; Lawrence Czer; Robert Vescio; Fardad Esmailian; Jon A. Kobashigawa is a Medicine article available to read on EtoBox.

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## Background: Cardiac amyloidosis (ca) has been historically noted with poor outcomes after heart transplant (htx). however, strict patient selection, appropriate multi-organ transplant, and aggressive post-transplant therapy can result in favorable outcomes. we present the experience in the largest single-center cohort of ca patients post-htx in the recent era. ## Methods: Between january 2010 and december 2018, 51 ca patients underwent htx-13 light-chain amyloidosis (al) and 38 transthyretin amyloidosis (attr), 49 were included. endpoints included 3-year survival, freedom from cardiac allograft vasculopathy (cav), and freedom from non-fatal major adverse cardiac events (nf-mace). ## Results: Overall 3-year survival was 81.6% (69.2% for al and 86% for attr) and was comparable to survival for patients transplanted for non-amyloid restrictive cardiomyopathy (rcm) in the same period (89%, p = .46). three-year freedom from cav (84% vs. 89%, p = .98), nf-mace (82% vs. 83%, p = .96), and any-treated rejection (95% vs. 89%, p = .54) were also comparable in both groups. no recurrence in amyloid was noted in endomyocardial biopsies. six patients (46%) with al amyloidosis underwent autolog

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Author

Gaurang N. Vaidya; Jignesh K. Patel; Michelle Kittleson; David H. Chang; Evan Kransdorf; Dael Geft; Lawrence Czer; Robert Vescio; Fardad Esmailian; Jon A. Kobashigawa

Publisher

Wiley

Published

2021

Language

EN

Field

Medicine (Health Sciences)