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Can I read IgG4-Related Disease: Beyond Glucocorticoids on EtoBox?
IgG4-Related Disease: Beyond Glucocorticoids by Mitsuhiro Akiyama; Tsutomu Takeuchi is a Medicine article available to read on EtoBox.
What is IgG4-Related Disease: Beyond Glucocorticoids about?
IgG4-related disease is a heterogeneous immune-mediated fibroinflammatory condition that can affect every single organ. This disease is more prevalent in the elderly (the mean age of patients is above 60 years) and the prevalence rate is estimated to be over 4.6 per 100,000 population. Before making a diagnosis, the exclusion of malignancies, lymphoma, anti-neutrophil cytoplasmic antibody-associated vasculitis, multicentric Castleman disease, and other mimickers is crucial for appropriate treatment. Broad management guidelines have been published emphasizing the need for prompt treatment and the use of glucocorticoids as first-line drug therapy for induction of remission. However, the toxic effects of glucocorticoids are problematic because IgG4-related disease is more prevalent in patients above 60 years of age, a population with frequent comorbid conditions and polypharmacy. Immunosuppressants (cyclophosphamide, methotrexate, leflunomide, and tacrolimus) and targeted immunomodulators (rituximab, XmAb5871, and abatacept) are appealing to overcome potential toxic effects of glucocorticoids and as emerging glucocorticoid-sparing and/or maintenance treatments. In this review, we prov
Who reads IgG4-Related Disease: Beyond Glucocorticoids?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Mitsuhiro Akiyama; Tsutomu Takeuchi
- Publisher
- Springer Science and Business Media LLC
- Published
- 2018
- Language
- EN
- Field
- Medicine (Health Sciences)