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Comparison of four sib-pair linkage methods for analyzing sibships with more than two affecteds: Interest of the binomial maximum likelihood approach by Laurent Abel; Alexandre Alcais; Alain Mallet is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Family samples collected for sib-pair linkage studies usually include some sibships with more than two affecteds (multiplex sibships). Several methods have been proposed to take into account these multiplex sibships, and four of them are discussed in this work. Two methods, which are the most widely used, are based on the number of alleles shared by the sib-pairs constitutive of the multiplex sibship, with the first using the total number of these shared alleles ("all possible pairs" method) and the second considering a weighted number of these alleles (weighted method). The two other approaches considered the sibship as a whole, with in particular a likelihood method based on a binomial distribution of parental alleles among affected offspring. We theoretically show that, in the analysis of sibships with two affecteds, this likelihood method is expected to be more powerful than the classical mean test when a common asymptotic type I error is used. The variation of the sibship informativeness (assessed by the proportion of heterozygous parents) according to the number of affected sibs is investigated under various genetic models. Simulations under the null hypothesis of no linkage

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Author

Laurent Abel; Alexandre Alcais; Alain Mallet

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0741-0395)

Published

1998

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)