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Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case–control study by Jaime Berumen; Lorena Orozco; Héctor Gallardo-Rincón; Fernando Rivas; Elizabeth Barrera; Rosa E. Benuto; Humberto García-Ortiz; Melissa Marin-Medina; Eligia Juárez-Torres; Anabel Alvarado-Silva; Espiridión Ramos-Martinez; Luis Alberto MartÍnez-Juárez; Julieta Lomelín-Gascón; Alejandra Montoya; Janinne Ortega-Montiel; Diego-Abelardo Alvarez-Hernández; Jorge Larriva-Shad; Roberto Tapia-Conyer is a Medicine article available to read on EtoBox.

What is Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case–control study about?

## Background This study investigated the effect of sex and age at type 2 diabetes (T2D) diagnosis on the influence of T2D-related genes, parental history of T2D, and obesity on T2D development. ## Methods In this case–control study, 1012 T2D cases and 1008 healthy subjects were selected from the Diabetes in Mexico Study database. Participants were stratified by sex and age at T2D diagnosis (early, ≤ 45 years; late, ≥ 46 years). Sixty-nine T2D-associated single nucleotide polymorphisms were explored and the percentage contribution (__R__^2^) of T2D-related genes, parental history of T2D, and obesity (body mass index [BMI] and waist–hip ratio [WHR]) on T2D development was calculated using univariate and multivariate logistic regression models. ## Results T2D-related genes influenced T2D development most in males who were diagnosed early (__R__^2^ = 23.5%; females, __R__^2^ = 13.5%; males and females diagnosed late, __R__^2^ = 11.9% and __R__^2^ = 7.3%, respectively). With an early diagnosis, insulin production-related genes were more influential in males (76.0% of __R__^2^) while peripheral insulin resistance-associated genes were more influential in females (52.3% of __R__^2^). Wit

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Author

Jaime Berumen; Lorena Orozco; Héctor Gallardo-Rincón; Fernando Rivas; Elizabeth Barrera; Rosa E. Benuto; Humberto García-Ortiz; Melissa Marin-Medina; Eligia Juárez-Torres; Anabel Alvarado-Silva; Espiridión Ramos-Martinez; Luis Alberto MartÍnez-Juárez; Julieta Lomelín-Gascón; Alejandra Montoya; Janinne Ortega-Montiel; Diego-Abelardo Alvarez-Hernández; Jorge Larriva-Shad; Roberto Tapia-Conyer

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)