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The Therapeutic Benefit of Antioxidants on the Outcome of Acute Aluminum Phosphide Poisoning: a Systemic Review and Meta-analysis by Zahraa K Sobh; Asmaa Abd-Elhameed is a Environmental Science article available to read on EtoBox.

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Abstract This systematic review and meta-analysis pool evidence available from clinical trials to verify the effect of antioxidants on the outcome of acute aluminum phosphide (AlP) poisoning. A systematic review complied with “Preferred Reporting Items for Systematic Reviews and Meta-Analyses” (PRISMA) Protocols. Meta-analysis was conducted on 10 studies that fulfill eligibility criteria. Four antioxidants were implemented: N-Acetyl cysteine (NAC), L-Carnitine, Vitamin E, and Co-enzyme Q10 (Co Q10). Risk of bias, publication bias, and heterogeneity were assessed to ensure the results’ reliability. Antioxidants significantly decrease mortality of acute AlP poisoning around three folds (OR = 2.684, 95% CI: 1.764–4.083; P < .001) and decrease the need for intubation and mechanical ventilation by two folds (OR = 2.391, 95% CI 1.480–3.863; P < .001) compared with control. Subgroup analysis revealed that NAC significantly decreases mortality by nearly three folds (OR = 2.752, 95% CI: 1.580–4.792; P < .001), and vitamin E significantly decreases mortality by nearly six folds (OR = 5.667, 95% CI: 1.178–27.254; P = .03) compared with control. L-Carnitine showed a borderline significance (P

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Author

Zahraa K Sobh; Asmaa Abd-Elhameed

Publisher

Oxford University Press (OUP)

Published

2023

Language

EN

Field

Environmental Science (Physical Sciences)