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This letter discusses the interference of Hemoglobin Hope in the measurement of HbA1c using the HPLC method, which can lead to falsely elevated results. The authors report two cases of patients with the Hb Hope variant who exhibited abnormal HbA1c levels when tested with the Bio-Rad D-10 analyzer, highlighting the need for careful review of chromatograms. They recommend using alternative methods, such as the Immunoturbidimetric Tina-quant assay, to avoid such interference in HbA1c measurements.

Author

pitipreya.veroj

Language

EN