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Trends and Prospects in Mitochondrial Genome Editing by Hong Thi Lam Phan; Hyunji Lee; Kyoungmi Kim is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Trends and Prospects in Mitochondrial Genome Editing about?

Mitochondria are of fundamental importance in programmed cell death, cellular metabolism, and intracellular calcium concentration modulation, and inheritable mitochondrial disorders via mitochondrial DNA (mtDNA) mutation cause several diseases in various organs and systems. Nevertheless, mtDNA editing, which plays an essential role in the treatment of mitochondrial disorders, still faces several challenges. Recently, programmable editing tools for mtDNA base editing, such as cytosine base editors derived from DddA (DdCBEs), transcription activator-like effector (TALE)-linked deaminase (TALED), and zinc finger deaminase (ZFD), have emerged with considerable potential for correcting pathogenic mtDNA variants. In this review, we depict recent advances in the field, including structural biology and repair mechanisms, and discuss the prospects of using base editing tools on mtDNA to broaden insight into their medical applicability for treating mitochondrial diseases.

Who reads Trends and Prospects in Mitochondrial Genome Editing?

Author

Hong Thi Lam Phan; Hyunji Lee; Kyoungmi Kim

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)