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Confirmatory Method for Macrolide Residues in Bovine Tissues by Micro-liquid Chromatography–tandem Mass Spectrometry by R. Draisci; L. Palleschi; E. Ferretti; L. Achene; A. Cecilia is a Chemistry article available to read on EtoBox.

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A new confirmatory method for three macrolides (tylosin, tilmicosin and erythromycin) in bovine muscle, liver and kidney by micro-LC-MS-MS using an atmospheric pressure ionisation source and an ionspray interface has been developed. ## 21 Roxithromycin was used as internal standard. The molecular related ions, [M12H] , at m /z 435 for tilmicosin, and 1 [M1H] , at m /z 734 and 916 for erythromycin and tylosin, respectively, were the precursor ions for collision-induceddissociation and two diagnostic product ions for each macrolide were identified for the unambiguous confirmation by selected reaction monitoring LC-MS-MS. Precision values (relative standard deviations) were all below 14.9%, whereas the overall accuracy (relative error) ranged from 217.7 to 29.8% for tylosin, from 217.5 to 210.7% for tilmicosin and from 219.6 to 213.7% for erythromycin, in all the investigated bovine tissues. The limits of quantification were 30 (muscle) or 40 21 21 21 (liver, kidney) mg kg , 20 (muscle) or 150 (liver, kidney) mg kg , 50 (muscle, liver) or 80 (kidney) mg kg , 20 (muscle, 21 liver) or 50 (kidney) mg kg for tylosin, tilmicosin, erytromycin and roxithromycin, respectively.

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Author

R. Draisci; L. Palleschi; E. Ferretti; L. Achene; A. Cecilia

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-3778)

Published

2001

Language

EN

Field

Chemistry (Physical Sciences)