Can I read A Charge-neutral Organic Cage Selectively Binds Strongly Hydrated Sulfate Anions in Water on EtoBox?

A Charge-neutral Organic Cage Selectively Binds Strongly Hydrated Sulfate Anions in Water by Liuyang Jing; Evelyne Deplazes; Jack K. Clegg; Xin Wu is a Chemistry article available to read on EtoBox.

What is A Charge-neutral Organic Cage Selectively Binds Strongly Hydrated Sulfate Anions in Water about?

In biological systems, enzymes and transport proteins can bind anions in aqueous media solely by forming hydrogen bonds with charge-neutral motifs. Reproducing this functionality in synthetic systems presents challenges and incurs high costs, particularly when targeting strongly hydrated anions such as sulfate. Here we report a [2.2.2]urea cryptand (cage), synthesized in one pot, that selectively binds sulfate in a mixture of dimethyl sulfoxide and water and in water with affinities in the micromolar to millimolar range. The neutral cage bearing six urea groups donates 12 strong hydrogen bonds to encapsulate a sulfate anion, showing favourable enthalpy even in pure water. Sulfate binding can be further enhanced by using micelles to provide a low-polarity microenvironment. The cage finds utility in analysing divalent anions in water and beverage samples or in removing sulfate. The work demonstrates the achievability of robust and selective anion binding in water with minimal synthetic efforts, by using neutral NH hydrogen bonds akin to those found in biology. Molecular receptors capable of selective anion binding in water provide opportunities for biomedical and industrial applicati

Who reads A Charge-neutral Organic Cage Selectively Binds Strongly Hydrated Sulfate Anions in Water?

Author

Liuyang Jing; Evelyne Deplazes; Jack K. Clegg; Xin Wu

Publisher

Springer Science and Business Media LLC

Published

2024

Language

EN

Field

Chemistry (Physical Sciences)