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Locus Coeruleus Activation Accelerates Perceptual Learning by Erin Glennon; Ioana Carcea; Ana Raquel O. Martins; Jasmin Multani; Ina Shehu; Mario A. Svirsky; Robert C. Froemke is a Neuroscience article available to read on EtoBox.
What is Locus Coeruleus Activation Accelerates Perceptual Learning about?
Neural representations of the external world are constructed and updated in a manner that depends on behavioral context. For neocortical networks, this contextual information is relayed by a diverse range of neuromodulatory systems, which govern attention and signal the value of internal state variables such as arousal, motivation, and stress. Neuromodulators enable cortical circuits to differentially process specific stimuli and modify synaptic strengths in order to maintain short- or long-term memory traces of significant perceptual events and behavioral episodes. One of the most important subcortical neuromodulatory systems for attention and arousal is the noradrenergic locus coeruleus. Here we report that the noradrenergic system can enhance behavior in rats performing a self-initiated auditory recognition task, and optogenetic stimulation of noradrenergic locus coeruleus neurons accelerated the rate at which trained rats began correctly responding to a change in reward contingency. Animals successively progressed through distinct behavioral epochs, including periods of perseverance and exploration that occurred much more rapidly when animals received locus coeruleus stimulatio
Who reads Locus Coeruleus Activation Accelerates Perceptual Learning?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Erin Glennon; Ioana Carcea; Ana Raquel O. Martins; Jasmin Multani; Ina Shehu; Mario A. Svirsky; Robert C. Froemke
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0006-8993)
- Published
- 2018
- Language
- EN
- Field
- Neuroscience (Life Sciences)