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P23-046-23 Dietary Curcumin Downregulates the Hepatic Cellular Senescence Pathway and Alters Gut Microbiota Composition in Aged Mice by Da-Yeon Lee; Jing Liu; Prabha Chandrasekaran; Guolong Zhang; Jennifer O'Connell; Josephine Egan; Yoo Kim is a Medicine article available to read on EtoBox.

What is P23-046-23 Dietary Curcumin Downregulates the Hepatic Cellular Senescence Pathway and Alters Gut Microbiota Composition in Aged Mice about?

Objectives: Aging is a time-dependent functional decline that causes cellular senescence in metabolic organs and dysbiosis, an imbalance of gut microbial community, eventually inducing agerelated metabolic disorders. Curcumin (CUR), the primary curcuminoid of turmeric, is well-known for its antioxidant and anti-inflammatory effects, but it is still unclear whether CUR has anti-aging properties and modulates gut microbiome. This study aimed to explore the role of CUR on hepatic cellular senescence and gut microbiota composition in a diet-induced obesity (DIO) aged mouse model. Methods: 18-20-month-old male C57BL/6 mice were fed a normal chow diet (NCD), a NCD with 0.4% (w/w) CUR (NCD +CUR), a high-fat high-sugar diet (HFHSD), or an HFHSD+CUR (n = 7-9 each) for 15 weeks. To identify the differentially expressed genes (DEGs) in the liver, we used RNA-Seq based on the Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. For validation of hepatic transcriptomic data, we conducted qPCR to analyze senescenceassociated secretory phenotypes (SASPs) and immunoblotting to detect proinflammatory proteins. Fecal samples before and after CUR supplementati

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Author

Da-Yeon Lee; Jing Liu; Prabha Chandrasekaran; Guolong Zhang; Jennifer O'Connell; Josephine Egan; Yoo Kim

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)