About this Medicine article
Increased risk of hospitalization for acute hepatitis in patients with previous exposure to NSAIDs by Chang-Hsing Lee; Jung-Der Wang; Pau-Chung Chen is a Medicine article available to read on EtoBox.
## Abstract ## Background Epidemiological studies related to hospitalization due to the hepatotoxicity of traditional non‐steroidal anti‐inflammatory drugs (NSAIDs) are infrequent, and case reports of hepatotoxicity of nimesulide, celecoxib, and rofecoxib seem to be increasing. The reimbursement database of National Health Insurance (NHI) in Taiwan provided an opportunity for post‐marketing surveillance. We conducted this study to determine the association between the use of hepatoxic NSAIDs and increased hospitalizations related to acute hepatitis. ## Methods We included hospitalized subjects with a major diagnosis of acute or sub‐acute necrosis of liver or toxic hepatitis and excluded viral and other causes of hepatobiliary diseases from the NHI database from 1 April 2001 to 31 December 2004. We applied two kinds of models to analyze by uni‐directional and bi‐directional case‐crossover designs during the 28 days exposure periods and performed conditional logistic regression models. ## Results There were 4519 cases of hospitalization relating to acute hepatitis, and the odds ratios of celecoxib, nimesulide, dicofenac, ibuprofen, and other hepatoxic NSAIDs were significantly increa
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- Author
- Chang-Hsing Lee; Jung-Der Wang; Pau-Chung Chen
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1053-8569)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)