Opening book details…
Can I read Astrocyte differentiation selectively upregulates CCL2/monocyte chemoattractant protein-1 in cultured human brain-derived progenitor cells on EtoBox?
Astrocyte differentiation selectively upregulates CCL2/monocyte chemoattractant protein-1 in cultured human brain-derived progenitor cells by Diane M.P. Lawrence; Pankaj Seth; Linda Durham; Frank Diaz; Roosevelt Boursiquot; Richard M. Ransohoff; Eugene O. Major is a Neuroscience article available to read on EtoBox.
What is Astrocyte differentiation selectively upregulates CCL2/monocyte chemoattractant protein-1 in cultured human brain-derived progenitor cells about?
## Abstract Chemokines (chemoattractant cytokines) and their receptors are present in the brain and may play roles in both neurodevelopment and neuropathology. Increased brain levels of monocyte chemoattractant protein‐1 (MCP‐1), also known as CCL2, are found in patients with human immunodeficiency virus type 1 (HIV‐1)‐associated dementia and other acute and chronic neurologic diseases. Although the function of CCL2 in the brain is unclear, it is believed that upregulation of this chemokine during neuropathologic or neuroinflammatory conditions leads to recruitment of activated monocytes into the brain, where they differentiate into macrophages producing neurotoxic and inflammatory molecules. We recently showed that human fetal brain‐derived progenitor cells are susceptible to HIV‐1 and JC virus infection, and that differentiation toward an astrocyte phenotype increased virus production from these cells. In the current study, we found that in the absence of infection, progenitors produced moderate levels of CCL2 (5.6 ng per million cells). Astrocyte differentiation over 3 weeks increased CCL2 protein levels 30‐fold in a biphasic manner, whereas neuronal differentiation decreased pr
Who reads Astrocyte differentiation selectively upregulates CCL2/monocyte chemoattractant protein-1 in cultured human brain-derived progenitor cells?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Diane M.P. Lawrence; Pankaj Seth; Linda Durham; Frank Diaz; Roosevelt Boursiquot; Richard M. Ransohoff; Eugene O. Major
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0894-1491)
- Published
- 2005
- Language
- EN
- Field
- Neuroscience (Life Sciences)