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Increasing serum antibodies against type B influenza virus in 2017–2018 winter in Beijing, China by Yao Yao; Lingling Chen; Dong Zhu; Runqing Li; Zhipeng Zhao; Wenqi Song; Xiuying Zhao; Kun Qin is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Increasing serum antibodies against type B influenza virus in 2017–2018 winter in Beijing, China about?

Abstract Influenza B virus circulates yearly with lower activity than that of influenza A virus in China. During winter 2017 to 2018, a sharp surge of influenza activity dominated by type B/Yamagata lineage virus caused unprecedented medical burden in Beijing. This research aimed to understand the underlying mechanism for this circulation and prepare for epidemics in the future. Sera samples collected from the patients in 2016–2017 and 2017–2018 flu seasons were tested for profiling hemagglutinin inhibition (HI) antibodies against both prevailing Victoria and Yamagata lineages of type B influenza viruses. It showed that the seroprevalence against both lineages of the virus in 2017–2018 winter was higher than that in 2016–2017, while no difference of the seroprevalence was observed between the two viruses. Meanwhile, significant elevated geometric mean titer (GMT) against both lineages of influenza B viruses was found in the specimens collected during 2017–2018 flu season than that from 2016 to 2017, suggesting the viruses might undergo antigenic changes. These results also suggested that lower GMT against both type B variants in 2016–2017 might serve as an immunological niche for t

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Author

Yao Yao; Lingling Chen; Dong Zhu; Runqing Li; Zhipeng Zhao; Wenqi Song; Xiuying Zhao; Kun Qin

Published

2022

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)