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Can I read Characterization of the Response to Myelin Basic Protein in a Non Human Primate Model for Multiple Sclerosis on EtoBox?
Characterization of the Response to Myelin Basic Protein in a Non Human Primate Model for Multiple Sclerosis by Antonio Uccelli; Debora Giunti; Gianluigi Mancardi; Francesco Caroli; Marialuce Fiorone; Marco Seri; Stephen L. Hauser; Claude P. Genain is a Immunology and Microbiology article available to read on EtoBox.
What is Characterization of the Response to Myelin Basic Protein in a Non Human Primate Model for Multiple Sclerosis about?
The common marmoset Callithrix jacchus (C. jacchus) is an outbred species characterized by a naturally occurring bone marrow chimerism and susceptibility to a form of experimental autoimmune encephalomyelitis (EAE) resembling multiple sclerosis (MS). T cell clones specific for the myelin antigen, myelin basic protein (MBP), can be derived from both naive and immunized marmosets and can adoptively transfer EAE to compatible chimeric siblings. Here, we demonstrate that severel different antigenic determinants of MBP are recognized by these encephalitogenic T cell clones. Furthermore, PCR-based analysis of TCR V g families does not show the preferential usage of any gene segment. Characterization of third complementarity determining regions (CDR3) fails to demonstrate a recurring motif characteristic of the T cell immune response to MBP in this species. Nevertheless, brief amino acid motifs are shared among marmoset clones and CDR3 sequences from MS samples. These data suggest that, due to its outbred condition, the C. jacchus marmoset mounts a diverse pathogenic response to MBP. However, the findings that certain CDR3 sequences are identically expressed in different animals, or by di
Who reads Characterization of the Response to Myelin Basic Protein in a Non Human Primate Model for Multiple Sclerosis?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Antonio Uccelli; Debora Giunti; Gianluigi Mancardi; Francesco Caroli; Marialuce Fiorone; Marco Seri; Stephen L. Hauser; Claude P. Genain
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 0014-2980)
- Published
- 2001
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)