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Evaluation of MISPE for the multi-residue extraction of β-agonists from calves urine by Christine Widstrand; Fredrik Larsson; Maurizio Fiori; Cinzia Civitareale; Sabrina Mirante; Gianfranco Brambilla is a Chemistry article available to read on EtoBox.

What is Evaluation of MISPE for the multi-residue extraction of β-agonists from calves urine about?

Methods based on molecular recognition mechanisms for the clean-up of veterinary drugs and their residues, such as immuno-, receptorand acceptor-affinity and molecularly imprinted polymers (MIPs), have been described as selective tools to improve the selectivity and the reliability of analytical results. In this work, we tested the extraction recovery performances of a MISPE column, designed for multi-residual clean-up of ␤-agonists. For this purpose, 18 different samples of calf urine were spiked at 0.25, 0.50 and 1.00 ppb with pooled standard solutions of clenbuterol (Clen), tulobuterol (Tolu), isoxsuprine (Isox), brombuterol (Brom), mapenterol (Mape) and ractopamine (Racto) and analysed on two independent analytical sessions, on a LC-MS/MS ion trap detector. Averaged recoveries, constant for each molecule considered, were 64.6% for Racto, 63.0% for Salm, 59.9% for Form, 54.7% for Brom, 52.0% for Clen, 41.8% for Mape, 38.6% for Tolu and 34.5% for Isox, respectively. Reproducibility studies gave a CV < 11% at the 0.25 ppb level. The decision limit for the identification of the target drugs ranged from 0.01 ppb for mapenterol to 0.19 ppb for salmeterol, when considering one precurs

Who reads Evaluation of MISPE for the multi-residue extraction of β-agonists from calves urine?

Author

Christine Widstrand; Fredrik Larsson; Maurizio Fiori; Cinzia Civitareale; Sabrina Mirante; Gianfranco Brambilla

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-376X)

Published

2004

Language

EN

Field

Chemistry (Physical Sciences)