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Sunscreen in vitro spectroscopy: application to UVA protection assessment and correlation with in vivo persistent pigment darkening by L. Ferrero; M. Pissavini; S. Marguerie; L. Zastrow is a Medicine article available to read on EtoBox.

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## Synopsis In the present study, we have described an __in vitro__ spectroscopic method to evaluate the sunscreen products for UVA sun protection factor. The roughened PMMA plates have been used as a transparent substrate on to which the test product is spread. The UVA protection factors have been deduced from the UV‐transmittance data measured in the UVA area. In order to be as close as possible to the __in vivo__ protection factors, issued from the PPD end‐point, the treated polymethylmethacrylate (PMMA) plates are submitted to different UV‐irradiation doses, before the measurement. The correlation __in vitro__/__in vivo__ is poor when the sunscreens are not irradiated. A UV dose of about 2 minimal pigmenting dose (MPD) is enough to achieve a good correlation between __in vitro__ and __in vivo__ data issued from the 13 tested sunscreens. These results are consistent with the fact that the photostability of sunscreens is challenged during an __in vivo__ PPD test.

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Author

L. Ferrero; M. Pissavini; S. Marguerie; L. Zastrow

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Springer Science and Business Media LLC; Wiley (ISSN 0142-5463)

Published

2002

Language

EN

Field

Medicine (Health Sciences)