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Mucinous (colloid) adenocarcinomas secrete distinct O‐acylated forms of sialomucins: a histochemical study of gastric, colorectal and breast adenocarcinomas by C Sáez; M A Japón; M A Poveda; D I Segura is a Medicine article available to read on EtoBox.

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**Mucinous (colloid) adenocarcinomas secrete distinct O‐acylated forms of sialomucins: a histochemical study of gastric, colorectal and breast adenocarcinomas** __Aims__: Mucinous (colloid) adenocarcinomas represent a distinct group of tumours defined by the presence of large amounts of extracellular mucins. By using histochemical methods, we analysed mucins secreted by mucinous versus non‐mucinous adenocarcinomas and looked for differential secretion profiles. __Methods and results__: Sixty‐four adenocarcinomas were studied (23 colorectal, 17 gastric, and 24 breast tumours). Thirty‐two tumours were of the colloid type. The following methods were applied to paraffin tissue sections: (i) Alcian blue (pH 2.5) and periodic acid–Schiff (PAS); (ii) high iron diamine and Alcian blue (pH 2.5); (iii) periodic acid borohydride, potassium hydroxide, and PAS; (iv) periodic acid–thionine Schiff, potassium hydroxide, and PAS; and (v) periodic acid–borohydride and PAS. Most adenocarcinomas secreted acidic mucins, with sialomucins predominating over sulfomucins, except for non‐mucinous adenocarcinomas of the breast which showed predominant neutral mucins. All mucinous adenocarcinomas contained C9

Who reads Mucinous (colloid) adenocarcinomas secrete distinct O‐acylated forms of sialomucins: a histochemical study of gastric, colorectal and breast adenocarcinomas?

Author

C Sáez; M A Japón; M A Poveda; D I Segura

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0309-0167)

Published

2001

Language

EN

Field

Medicine (Health Sciences)