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Evaluation of Apoptosis and Micronucleation Induced by Reactor Neutron Beams with Two Different Cadmium Ratios in Total and Quiescent Cell Populations Within Solid Tumors by Shin-ichiro Masunaga; Koji Ono; Yoshinori Sakurai; Masao Takagaki; Tooru Kobayashi; Yuko Kinashi; Minoru Suzuki is a Medicine article available to read on EtoBox.
What is Evaluation of Apoptosis and Micronucleation Induced by Reactor Neutron Beams with Two Different Cadmium Ratios in Total and Quiescent Cell Populations Within Solid Tumors about?
## Purpose: Response of quiescent (q) and total tumor cells in solid tumors to reactor neutron beam irradiation with two different cadmium (cd) ratios was examined in terms of micronucleus (mn) frequency and apoptosis frequency, using four different tumor cell lines. ## Methods and materials: C57bl mice bearing el4 tumors, c3h/he mice bearing scc vii or fm3a tumors, and balb/c mice bearing emt6/ku tumors received 5-bromo-2'-deoxyuridine (brdu) continuously for 5 days via implanted mini-osmotic pumps to label all proliferating (p) cells. thirty min after i.p. injection of sodium borocaptate-10b (bsh), or 3 h after oral administration of p-boronophenylalanine-10b (bpa), the tumors were irradiated with neutron beams. the tumors without 10b-compound administration were irradiated with neutron beams or gamma-rays. this neutron beam irradiation was performed using neutrons with two different cd ratios. the tumors were then excised, minced, and trypsinized. the tumor cell suspensions thus obtained were incubated with cytochalasin-b (a cytokinesis blocker), and the mn frequency in cells without brdu labeling (=q cells) was determined using immunofluorescence staining for brdu. meanwhile, f
Who reads Evaluation of Apoptosis and Micronucleation Induced by Reactor Neutron Beams with Two Different Cadmium Ratios in Total and Quiescent Cell Populations Within Solid Tumors?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Shin-ichiro Masunaga; Koji Ono; Yoshinori Sakurai; Masao Takagaki; Tooru Kobayashi; Yuko Kinashi; Minoru Suzuki
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)